Source

Curcuma longa (Turmeric)

Active components

Curcuminoids

Nutraceutical applications

Antioxidant

Anti-inflammatory support

Immune support

Plant part used

Roots


Patents

U.S. PATENT #5,861,415 (1999)

INTERNATIONAL PATENT: European Patent # EP0839037 (2002)


Beneficial Effects of Curcuminoids

  • Curcumin C3 Complex® is an effective "Bioprotectant”, antioxidant quenching free radicals and also preventing their formation1
  • Curcumin has been shown to be a COX-2 (Cyclooxygenase-2) inhibitor1
  • Unlike conventional non steroidal anti-inflammatory drugs (NSAIDs), curcuminoids do not cause gastrointestinal side effects or ulcers
  • Curcuminoids support a healthy immune system1
  • Prevent connective tissue break down through inhibiting destructive enzymes2

Nutraceutical Applications of Curcuminoids

  • Antioxidant support
  • Alzheimer’s disease/dementia
  • Cardiovascular support
  • Immune support/Anti-tumor/Anticancer effects, Anti-inflammatory support
  • Wound healing
    • For example: Rheumatoid arthritis, postoperative inflammation, colorectal cancer, bladder cancer, oral leucoplakia, psoriasis, antiviral effects

Pharmacology & Clinical Trials

  1. Curcumin/Piperine - IND study approved: IND# 61,872
    • Food & Drug Administration Office of Drug Evaluation I, Division of Oncology Drug Products
  2. The effects of Curcuminoids on aberrant crypt foci in the human colon: IND# 51,685
    • UMDNJ- Robert Wood Johnson Medical School, New Jersey Cancer Institute
  3. Pilot study of curcuminoids with or without BioPerine® in patients with multiple myeloma: IND# 67,963
    • MD Anderson Cancer Center, University of Texas
  4. Prevention and intervention ofAlzheimer's disease with curcuminoids: - University of California, Los Angeles
  5. Curcuminoids in patients with Lichen planus: IND#65,700/S-000 - University of California
  6. Phase IIa prevention study of C3 Complex® curcuminoids in women at increased risk for breast cancer
    • MD Anderson Cancer Center, University of Texas
  7. The clinical and laboratory effects of topical curcuminoids in patients with normal skin and with dysplastic and benign nevi
    • National Cancer Institute
  8. Phase II prevention study with C3 Complex® in patients with colorectal cancer stage I-III
    • Lincoln Medical and Mental Health Center, Bronx, NY
  9. Phase I trial of C3 Complex® and precooperative patients with locally advanced esophageal or gastroesophageal carcinoma
    • MD Anderson Cancer Center, University of Texas
  10. Metabolic studies and chemopreventive studies -University of Leicester, UK

References

1 - www.curcuminoids.com

2 - Liacini, A. et al. Matrix Biol. 2002 Apr;21(3):251-62


LactoSpore®

  • A versatile probiotic
  • Lactic Acid Bacillus
    • Originally known in literature as Lactobacillus sporogenes
    • also known as Bacillus coagulans
    • L. sporogenes was first isolated and described in 1933 by L.M. Horowitz Wlassowa & N.W. Nowotelnow
  • Documented clinical effectiveness

Characteristic Features

  • Gram positive, Indole negative, rod shaped bacteria with terminal spores
  • Produces L(+) Lactic Acid only
  • Naturally microencapsulated for stability
  • Proliferates within the GI tract
  • Extremely fastidious organisms
  • Grow optimally at 30°C to 37°C & optimum pH in the range 5.5 to 6.2
  • Microaerophilic
  • The acidic environment created by production of L(+) Lactic Acid & other antimicrobial compounds prevents the growth of disease causing microbes like Clostridia, which are responsible for production of undesirable gases
  • Long & slender cells (0.3 to 0.8 microns)
  • Colonies are usually 2.5 mm in diameter, convex, smooth, glistening and do not produce any pigment

Lactobacillus sporogenes

Lactobacillus sporogenes

Temperature Stability

  • Due to spore forming nature, LactoSpore® survives manufacturing, shipping and storage with no loss of viable count
  • Does not require refrigeration conditions
  • Cardiovascular support
  • Room temperature stable

Lactic Acid Production

  • LactoSpore® produces only L (+) Lactic acid, which is completely and efficiently metabolized to glycogen
  • Whereas other probiotics may produce D (-) Lactic acid, which is metabolized slowly and in excess, can cause metabolic acidosis and may even be toxic to the brain

Gastrointestinal Health

Indicated for improvement of symptoms due to abnormalities in intestinal flora. A total of 567 cases in 19 institutions in Japan were evaluated.1

Condition % cases showing
improvement
Number of patients
showing improvement
Diarrhea due to acute or
chronic gastroenteritis
93.7 118/126
Maldigestion
accompanied with
diarrhea
85.9 79/92
Infantile diarrhea 87.9 58/66
Constipation 65.4 17/26

1 - Abstracts of papers on the clinical study of Lacbon (Sporlac) compiled by the Sankyo Co. Ltd. Japan

Gastrointestinal Health: Studies in India

Study 1: Cases of neonatal diarrhea responded well to L. sporogenes (SPORLAC) therapy. 60 diarrheal cases of which three also suffered from constipation and three from jaundice were studied.

Dose administered: 15 million spores per day

Recovery period: 15 million spores per day

Recovery period: 1.8 days

Results summary for diarrheal symptoms:

Condition Cases Treated Cases Cured Success Rate
Diarrhea 60 49 81.7%
Constipation 3 3 100%
Jaundice 3 3 100%

Dhongade, R.K., Anjaneyulu, R. (1977). Abstract from Maharashtra Medical Journal Vol.XXIII No.1, Feb: 473-474



Study 2: 112 newborn infants in rural India were randomized to receive a daily oral dose of 100 million L. sporogenes or a placebo for one year.

Morbidity was monitored each week for 12 months.

Effect of L. Sporogenes feeding on rotavirus diarrhea
  L. Sporogenes Placebo p
Number of Infants 55 57  
Number of Infants
with
Rotovirus Diarrhea
44 50 NS
Number of
episodes
3.4 (1.0) 8.6 (1.7) <0.02
Duration of each
episode (days)
3.6 (1.0) 6.8 (1.1) <0.05
Days ill /
12 months
13 (3) 35 (5) <0.01
Data are shown as mean (SD). NS: statistically not significant

Chandra, R.K. Nutrition Research 22 (2002) 65–69


Other Clinical Studies: Healthy Serum Lipid Profiles

Short term hypolipidemic effects of oral L. sporogenes therapy

Dose: 360 million spores per day in tablet form

Subjects: 7 patients (15 men and 2 women in the 32-61 year age group) with type II hyperlipidemia in an open label fixed dose trial.

Duration: 12 weeks

Atherogenic Lipid Ratios were improved:

Total/HDL cholesterol ratio: Decreased by 27%

LDL/HDL ratio: Decreased by 33.4%

J.C. Mohan, R. Arora & M. Khalilullah, Indian Journal of Medical Research [B], 92:431-432 (1990)


Results of the Study


lactospore results

Clinical Study: Non-Specific Vaginitis

Study 2:44 patients with non-specific vaginitis [12 with leucorrhea after cervical surgery; 32 (26 of reproductive age and 6 postmenopausal, without previous therapy)]

Dose:2 vaginal tablets/day (150 million spores/tab.)

7-14 days


Results:


Complete relief: 91% cases

Partial relief: 9% cases

In a similar clinical trial using M.T.P. vaginal peccaries containing broxyquinoline and brobenzoxeldine where only 26.67% of cases studied were cured.

Conclusion:Lactobacillus sporogenes is effective in non-specific vaginitis by raising the vaginal acidity, and thereby checking the growth of pathogenic organisms.


Non-Specific Vaginitis

lactospore vaginal pH

Sankholkar, P.C and Sali, M.S. Clinical study report from B.J. Medical College, Pune, India


Aphthous stomatitis and glossitis

  • Recurrent oral lesions respond well to Lactobacillus sporogenes therapy

120 million spores supplied in three divided doses (in the form of SPORLAC, a tabletted preparation) for three days was found to be effective in human volunteers.

Mathur, S.N. et al. (1970). UP State Dental Journal 11:7-12


Other Health Benefits in Infants

Condition: Allergic Skin Diseases

  • No. of subjects: 5
  • Treatment: 200-450 million spores / day in divided doses for 4-12 days
  • Effectiveness rate: 80.0%

Conclusion: Obvious eruptions of strophulus and eczema decreased from the third day (topical therapy employed concomitantly)


Condition: Miscellaneous Symptoms

  • No. of subjects: 10
  • Treatment: 20-50 million spores / day in divided doses for 4-20 days
  • Effectiveness rate: 80.0%

Conclusion: Response seen in anorexia of nervous type and malnutrition in infants

Abstracts of papers on the clinical study of Lacbon (Sporlac) compiled by the Sankyo Co. Ltd. Japan



Lactospore Gastrointestinal Growth pH Lactospore Gastrointestinal Growth pH

Advantages of LactoSpore®

  • Produces L(+) Lactic acid only
  • Produces Bacteriocin
  • Room temperature stable
  • Clinical studies have revealed that it can be successfully implanted in the intestine

  • BioPerine® is a patented standardized extract obtained from black pepper, containing not less than 95% piperine
  • A clinically proven bioavailability enhancer for nutrients1

Bioavailability

  • Bioavailability is “the quantity of a substance, either nutrient, drug, or toxicant, that effectively reaches the target cells where it modifies, for good or bad, their metabolism and consequently their fate”.1

1 Basu, T.K.: The influence of drugs with particular reference to aspirin on bioavailability of Vitamin C; in Counsell, Hornig, Vitamin C, pp.273-281 (Applied Science Publishers, Barking 1981)


Characteristic Features

  • Gram positive, Indole negative, rod shaped bacteria with terminal spores
  • Produces L(+) Lactic Acid only
  • Naturally microencapsulated for stability
  • Proliferates within the GI tract
  • Extremely fastidious organisms
  • Grow optimally at 30°C to 37°C & optimum pH in the range 5.5 to 6.2
  • Microaerophilic
  • The acidic environment created by production of L(+) Lactic Acid & other antimicrobial compounds prevents the growth of disease causing microbes like Clostridia, which are responsible for production of undesirable gases
  • Long & slender cells (0.3 to 0.8 microns)
  • Colonies are usually 2.5 mm in diameter, convex, smooth, glistening and do not produce any pigment

A natural bioavailability enhancer for nutrients
  • Herbal extracts
    • e.g. curcumin, Boswellin®, ashwagandha, Gingko biloba, capsaicin
  • Water-soluble vitamins
    • e.g. vitamin B1, vitamin B2, niacinamide, vitamin B6, vitamin B12, folic acid, vitamin C
  • Fat-soluble vitamins
    • e.g. vitamin A, vitamin D, vitamin E, vitamin K
  • Antioxidants
    • e.g. vitamin A, vitamin C, vitamin E, alpha-carotene, transbeta-carotene, beta-cryptoxanthin, lycopene, lutein/zeaxanthin, pine bark bioflavanoids complex, germanium, selenium, zinc
  • Amino Acids
    • e.g. lysine, isoleucine, leucine, threonoine, valine, tryptophan, phenylalanine, methionine
  • Minerals
    • e.g calcium, iron, zinc, vanadium, selenium, chromium, iodine, potassium, manganese, copper, magnesium

Possible mechanisms for increased nutrient bioavailability using BioPerine®

  • Non specific mechanisms promoting rapid absorption of nutrients
    • Increases blood supply to the GI tract
  • Water-soluble vitamins
    • Increases emulsifying content of the gut
  • Fat-soluble vitamins
    • Increases active nutrient transport

Average daily consumption of piperine with black pepper vs. daily requirements for BioPerine®

Average daily consumption of piperine with black pepper vs. daily requirements for BioPerine®

*Estimated daily consumption of piperine with black pepper
Data based on doctoral thesis by Shore Scott Kindell, Drexel University, 1984
** Estimated daily consumption of BioPerine®


“Once the window of opportunity for piperine-nutrient interaction has been missed nutrient absorption is not enhanced”

-Nutrition Science News, March 1996


BioPerine® increased the absorption of co-administered beta-carotene in human volunteers

Average daily consumption of piperine with black pepper vs. daily requirements for BioPerine®

*Estimated daily consumption of piperine with black pepper
Data based on doctoral thesis by Shore Scott Kindell, Drexel University, 1984
** Estimated daily consumption of BioPerine®


Effect of BioPerine® on serum selenium levels during a 6 week supplementation trial in human volunteers

Average daily consumption of piperine with black pepper vs. daily requirements for BioPerine®

Efficacy of BioPerine® (5 mg) on the bioavailability of Vitamin B6 absorption in human volunteers

Efficacy of BioPerine® (5 mg) on the bioavailability of Vitamin B6 absorption in human volunteers

Effect of BioPerine® on serum CoQ10 levels during a 21 day supplementation trial

Effect of BioPerine® on serum CoQ10 levels during a 21 day supplementation trial

Effect of BioPerine® on Serum Concentrations of Curcumin in Human Volunteers

Effect of BioPerine® on Serum Concentrations of
Curcumin in Human Volunteers

Multivitamin Bioavailability (+/- Piperine)

  • Piperine supplementation significantly increased the bioavailability of vitamin C and vitamin E from the standard multivitamin formulation
  • The bioavailability of vitamin B6, B12, Betacarotene, or calcium was improved with piperine supplementation

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